Name: IL33 Mouse Monoclonal Description: Mouse Monoclonal Antibody to IL33 Specificity: Human Applications: ELISA, WB (Recommended dilutionWB: 1:500-1:2000; IHC: 1:50-1:500) Immunogen: interleukin 33 (Calculated MW:35kd) Host: Mouse Clonality: Monoclonal Isotype: IgG1 Conjugate: Unconjugated Purity: Protein A+G purification (≥95% as determined by SDS-PAGE) Product Form: Liquid Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Background Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells(PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an “alarmin”, that amplifies immune responses during tissue injury(PubMed:17853410, PubMed:18836528).
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets(PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation(PubMed:18787100).
Uniprot information:
Gene Name IL33
Uniprot ID O95760
Target:
Synonyms: C9orf26 Antibody
CHROMOSOME 9 OPEN READING FRAME 26 Antibody
DKFZp586H0523 Antibody
DVS27 Antibody
DVS27 related protein Antibody
IL 1F11 Antibody
IL 33 Antibody
IL-1F11 Antibody
IL-33 Antibody
IL1F11 Antibody
IL33_HUMAN Antibody
Interleukin 1 family member 11 Antibody
Interleukin 33 Antibody
INTERLEUKIN 33 NFHEV Antibody
Interleukin 33 precursor Antibody
Interleukin-1 family member 11 Antibody
Interleukin-33 (109-270) Antibody
Interleukin33 Antibody
NF HEV Antibody
NF-HEV Antibody
NFEHEV Antibody
NFHEV Antibody
Nuclear factor for high endothelial venules Antibody
Nuclear factor from high endothelial venules Antibody
OTTHUMP00000021041 Antibody
RP11 575C20.2 Antibody
Research Areas:
Cardiovascular → Angiogenesis → Cytokines → Other
Immunology → Innate Immunity → Cytokines → InterleukinsCardiovascular → Heart → Hypertrophy → Other
Please Note: IL33 Mouse Monoclonal is for research use only. It is not intended for diagnostic or therapeutic use.